Diffuse infiltrating retinoblastoma.

Diffuse infiltrating retinoblastoma.

The term "diffuse infiltrating retinoblastoma" was introduced by Ashton (1958) to describe a form of retinoblastoma which did not produce a tumour mass within the retina. Although Manschot (1956) and Weizenblatt (I957) had described such cases previously, they did not recognize the condition as a distinct entity. Schofield (1960) described four cases of this type of retinoblastoma which present...

Diffuse infiltrating retinoblastoma invading subarachnoid space

We report herein an unusual case of diffuse infiltrating retinoblastoma involving the brain, which caused a patient's death 27 months after enucleation. An eight-year-old boy complained of blurred vision in his right eye (OD) in October 2006. Funduscopic examination showed optic disc swelling, dense whitish vitreous opacity, and an orange-colored subretinal elevated lesion adjacent to the optic...

Teaching NeuroImages: A diffuse infiltrating retinoblastoma.

Diffuse infiltrating retinoblastoma with central nervous system metastasis.

Comment. Both MEB disease and Walker-Warburg syndrome have underlying deficiencies in posttranslational glycosylation of -dystroglycan that lead to severe defects in organogenesis and neuronal migration. Brain and eye phenotypes in MEB disease and WalkerWarburg syndrome likely involve defective glycosylation in proteins other than -dystroglycan since chimeric mice deficient in -dystroglycan dev...

Clinical Presentation and Genetic Paradigm of Diffuse Infiltrating Retinoblastoma: A Review.

Retinoblastoma is the most common childhood cancer. Thanks to modern technology and good medical access, mortality in Europe has decreased to about 5%. Diffuse infiltrating retinoblastoma is a very rare subtype of this neoplasm and is characterized by its atypical growth pattern. Diffuse infiltrating retinoblastoma may mimic other more innocuous diseases and may therefore be misdiagnosed. The p...